Official Tehran issued a harsh statement, effectively jeopardizing the prospects of concluding a "grand bargain" with Washington, which American leaders had previously mentioned. The Iranian Ministry of Foreign Affairs officially declared enriched uranium an inviolable national treasure that cannot be transferred to foreign countries under any circumstances. The ministry emphasized that the country's nuclear resources are as sacred as its territory itself, and any demands for their removal beyond its borders are considered an infringement on the sovereignty and national pride of the Iranian people.

Iranian Foreign Ministry spokesman Esmail Baghaei clarified during a special briefing that the option of handing over the accumulated uranium to the United States was never on the negotiating agenda and was not even considered by the country's leadership as a possible compromise. According to the diplomat, the Islamic Republic's position on this issue remains unwavering: the country intends to independently manage its nuclear materials, which Tehran considers the result of years of scientific work and significant financial investments. This statement was a direct response to recent demands from US Vice President J.D. Vance, who cited the removal of Iranian nuclear materials as a key and fundamental condition for scaling back the American military operation in the region.